1 Title : PDLIM 1 stabilizes the E - cadherin / β - catenin complex to prevent epithelial - 2 mesenchymal transition and metastatic potential of colorectal cancer cells

Title Page 1 Title: PDLIM1 stabilizes the E-cadherin/β-catenin complex to prevent epithelial2 mesenchymal transition and metastatic potential of colorectal cancer cells 3 4 Authors: Hai-Ning Chen, Kefei Yuan, Na Xie, Kui Wang, Zhao Huang , Yan Chen, 5 Qianhui Dou, Min Wu, Edouard C. Nice, Zong-Guang Zhou, Canhua Huang 6 7 Affiliations: 8 1. Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy and Cancer 9 Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for 10 Biotherapy, Chengdu, P.R. China; 11 2. Department of Biochemistry and Molecular Biology, University of North Dakota, Grand 12 Forks, ND, US. 13 3. Department of Biochemistry and Molecular Biology, Monash University, Clayton, 14 Victoria, 3800, Australia and Visiting Professor, The State Key Laboratory of 15 Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan 16 University, Chengdu, P.R. China. 17 4. These authors contributed equally to this work. 18 19 Correspondence: 20 Prof. Zong-Guang Zhou, Department of Gastrointestinal Surgery, West China Hospital, 21 Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, People's Republic of China. 22 Phone.: +86-28-85422879; Fax: +86-28-85164035; Email: [email protected] 23